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What Are the Best Materials for Medical Tubing?


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Medical tubing looks simple, but its material selection determines performance, safety and regulatory success. The right compound affects everything from flow control and biocompatibility to sterilization compatibility. This guide breaks down the most common materials for medical tubing, compares their strengths and explains how engineers can choose the best fit for regulated medical systems.

Why Material Selection Is Critical in Medical Tubing

Tubing is essential across respiratory care, IV lines, peristaltic pumps, drainage systems and diagnostic devices. Because tubing often interfaces with the body, biocompatibility, cleanliness and chemical stability are mandatory.

Material choice influences:

  • Consistent flow and mechanical durability
  • Compatibility with drugs, fluids and disinfectants
  • Sterilization method tolerance
  • Compliance with FDA 21 CFR, ISO 10993 and USP Class VI

Sur-Seal helps OEMs select materials that balance performance, safety and manufacturability — especially in single-use and reusable medical systems.

Key Performance Criteria for Medical Tubing Materials

Engineers should evaluate:

  • Biocompatibility: Must be proven safe for skin, tissue or fluid contact
  • Sterilization compatibility: Ability to withstand EtO, autoclave, gamma or e-beam sterilization
  • Chemical and temperature resistance: Prevents reactions, leaching or degradation
  • Flexibility and durometer: Determines kink resistance and flow consistency
  • Bonding and assembly compatibility: Must work with fittings, adhesives or thermal joining

These criteria guide whether silicone, plastic or rubber performs best in the final design.

The Best Medical Tubing Materials

Silicone Tubing: Silicone is an industry standard for high-performance and implantable systems.

Benefits:

  • Flexible, inert and highly biocompatible
  • Handles repeated sterilization (EtO, steam, gamma)
  • Performs well in peristaltic pumps and respiratory systems

Sur-Seal supports silicone converting for slitting, laminating and die-cutting. Explore our silicone materials.

Plastic Tubing (PVC, PE, PP, Polycarbonate)

PVC dominates single-use medical tubing due to low cost and excellent clarity. PE and PP offer chemical resistance, while polycarbonate provides rigidity when structural stability is required.

Common Uses:

  • Diagnostic lines
  • Drainage tubing
  • IV sets
  • Low-pressure fluid transfer

At Sur-Seal, we help OEMs select plastics that achieve the right mix of clarity, sterilization compatibility and bond strength.

Rubber-Based Tubing (EPDM, Neoprene, Nitrile)

Rubber tubing offers resilience and durability under pressure or repeated flexing.

Common Uses:

  • Suction tubing
  • Blood pressure cuffs
  • Anesthesia lines

Medical rubber compounds can be formulated to meet the performance requirements of ISO 10993.

Foams and Adhesive-Backed Tubing Solutions

Foams and pressure-sensitive adhesives (PSAs) are often paired with tubing to add stability or comfort.

Applications:

  • Cushioning around tubing channels
  • Fixation layers for wearable or portable devices
  • Thermal or vibration barriers

Sur-Seal’s medical-grade foam and PSA capabilities create cleaner, safer system integration. See our medical solutions.

Comparing Silicone vs. Plastic vs. Rubber Tubing

Property Silicone Plastic Rubber
Biocompatibility Excellent Varies Good
Sterilization Resistance High Moderate Good
Flexibility High Moderate High
Chemical Resistance High Moderate High
Cost Mid-high Low Mid

Regulatory Standards for Medical Tubing

Common requirements include:

  • USP Class VI for toxicity
  • ISO 10993 for biocompatibility
  • FDA 21 CFR for material safety

Sur-Seal’s validated converting processes, documentation and material traceability help support OEM compliance needs.

Material Compatibility with Sterilization

  • EtO: Safe for most plastics, silicone and rubber
  • Autoclave: Best for silicone and certain rubber compounds
  • Gamma/e-beam: Can damage PVC; silicone remains stable

Matching the sterilization method to the material is essential for maintaining performance, clarity and flexibility.

Sur-Seal’s Expertise in Medical Tubing Materials

Sur-Seal provides:

  • Precision slitting
  • Laminating
  • Die-cutting
  • Cleanroom converting
  • Material validation support

Partnership early in development leads to faster prototyping and simplified regulatory pathways.

Contact Sur-Seal for help selecting materials for medical tubing.

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